For sure, I just get antsy when peer review doesn’t come from from external sources

1 patient, T2 since mid-30s and now 59, had kidney transplant 2017 after end-stage diabetic nephropathy and fucked glucose control since 2019. The successful cells were endoderm stem cells from him cultivated by mice they injected with his PBMCs that they then made diabetic. So not from cadavers (except mouse cadaver i guess), which is the actual new part here. Intrahepatic implant, and cells from unrelated donor failed that were embedded at the same time. His personalised mouse-donor cells worked well enough to take him off insulin 3 months later.

Wu, J., Li, T., Guo, M. et al. Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov 10, 45 (2024).

It’s good news, but you’re entirely correct that the article missed the point entirely. Thanks for the crash course in islet cell therapy!

Hm, 5 year old journal, with the editor board, funding and half of the authors all from the Chinese Academy of Sciences, but significant hospital contribution. I remain skeptical of the headline but hopeful of the science.

Looming? Sudan is past the looming stage. When do known verified atrocities reach “current reality” status?

I once looked at a job listing for something with very specialist technical knowledge in specific programming areas, for a Japanese company based in Tokyo (pre-covid so remote wasn’t really a thing yet). Pretty niche stuff and needed at least basic Japanese language skills too, so I assumed it would pay ok - even if it wasn’t good or great in comparison with jobs where i was.

After conversion it worked out to be around USD$40k a year, which is probably just over 1/3 of what it would pay at minimum elsewhere. More like 1/4 or less for Silicon Valley type locations, but the rent for a tiny Tokyo shoebox is about the same price even if food is a cheaper. There was no way I was applying for that.

It isn’t just about a weak yen, it’s much more about hugely underpaying people.

It annoyed me that I couldn’t see the whole statue. It’s just a statue of the local general but another part of the inscription was also interesting:

THE CONFEDERATE SOLDIER WON AND IS ENTITLED TO THE ADMIRATION OF ALL WHO LOVE HONOR, AND LIBERTY.

Uh huh. From a monument built 50 years after the war ended. Physical copium.

I’ve always considered doing a raid array but the cheapness of remote servers these days makes it feel like overkill combined with being expensive and centralized. I just have an external enclosure and a mess of duplicate files across smaller outdated drives at the moment. It’s not ideal, but that’s ADHD for you.

That’s probably it, thanks. Good to know it’s just a firmware issue too

Yep, got a Samsung evo 870 in there, still going strong for like a decade. The HGST spinner I have is also pretty longlived. Weren’t they bought out by WD though? I feel like I remember hearing that the quality has declined severely.

Having said that, I do also have a WD … black? In there that has also lasted. I will check out gold though, and the mx500

backblaze drive failure report

Excellent, this is what I was hoping to find again but i couldn’t remember the name. I also assumed it would be paywalled after all these years… if I could even get google to deliver the link.

Thanks a heap, you’ve been extremely helpful!

The world’s population is getting significantly sicker and we’re blaming the victims for “lifestyle diseases” as a way of dismissing the problem. But research needs money and time, so there will always be better and stronger evidence for money-making remedies instead of the slow and complex research into why people are increasingly experiencing disease.

We’re hurting ourselves, and each other, and because disabled people are excluded from huge parts of society, we’re also covering up the evidence. It’s only when we’re wounded that the reality is clear, but by then it’s too late - you’re just written off as someone who made bad choices.

Sounds like we had the same programmers. I feel you, Kairos.

Why would I give them a vote of confidence with my money so that they can use it to convince investors that they’re popular and they should pony up a billion dollars for Spez’s pay?

They’re relying on gullible people who think either Reddit is legitimately a good investment or gullible people who think they can beat the market and won’t be left holding the bag. I’m nobody’s bag holder, let alone Spez’s.

if I can quickly make a couple of bucks and then cash out, that might be worth it.

Said every gambler ever.

Thanks for understanding and being willing to consider a stranger’s point of view, I appreciate it.

what happened was a logical and known potential outcome and consequence of signing up

It certainly is, but when the burden of responsibility is only placed on the person at the end of the line, it lets the fuckers at the top with the unequal power skirt their responsibility. Perhaps “blame” is too far, but it doss seem like you’ve perhaps disproportionately assigned blame to thus one shouting guy and his kid.

You make it sound as if the choice is binary between starving and joining the military: it’s not.

Not at all, but I do acknowledge that for many, and in increasing amounts, the decision has indeed become very close to that binary. US hegemony relies on people to do the enforcement. That’s obviously dangerous, and thankfully, despite pervasive cultural conditioning, most people aren’t interested in killing others overseas while living in an overcrowded dorm eating slop. So the conditions have been put in place by the ruling class to force people into doing it.

If you’re unlucky enough to be born in Podunk Nowhere, where disaster capitalism has resulted in the only employers being Walmart, mcdonalds or the shady abattoir that “hires” minors, you don’t start with many options. Add in an “education” from a system that has been rotted from within by zealots, complete with in-school army recruiter. Add in a culture that loves guns. Add in a family member in debt from medical accident (probably at the abattoir), or an unplanned pregnancy because of no access to abortion. Maybe they’re also living at home with a parent who is addicted to meth out of desperation to avoid their poverty and misery… and the military starts looking like a very tempting option.

You have the chance of dying and disability in the military, and the likelihood that you’re forced to murder, but also the glimmer of hope of an education, family healthcare and a way out of Podunk’s cycle of poverty. That’s a powerful motivator for someone who doesn’t see any other realistic options. It’s a deliberate funnel into committing murder through economic coercion and military worship culture, and the fault lies with the trap makers, not the trapped.

The only thing that makes the last 80 years different is the efficiency of murder and the new murder weapons they have access to.

And the extent of its reach. A century ago, the US was pretty limited to war on North American soil, and land it claims. When the war is that close, the realities of suffering are hard to conceal from the people whom you need to inflict it. Wars in other continents though can be sanitized by the media, and the people who are caught in the military funnel trap find out after they’ve signed the contract.

Thankfully the prevalence of video tech has allowed us to mitigate some of that media sanitization, but again, putting the burden of responsibility on the 18 year old who has never been taught critical thinking skills allows the 65+ year old networked decision makers at the top to slide off the hook.

Tl;dr I think it’s OK to acknowledge everything on all fronts is fucked for everyone except the ruling class. I also think it’s OK to shout at the ruling class, even in their house, when you were invited to be there.

Blaming the people who need to eat instead of the people creating an economy out of death and misery is counter-productive. US foreign policy and economics have centered around war for at least 80 years, Biden has played a crucial role in facilitating it for a few decades.

And the fact a person has been arrested for shouting at the president in the same location where people literally stormed it and engaged in literal violence and walked away free that day? Amazing.

Biden might be infinitely better than the alternative for most citizens of the US (and likely the entire world) - but the non-US part of the world has been bearing the costs of the US military economy that has provided the privileges US citizens currently enjoy.

But fuck the guy who lost his kid, right? He’s the real problem. /s

Israel Appropriates. Very interesting language.

All the reports Reuters makes on the
Russia war treats land ownership quite differently. When Ukraine takes land they say “Ukraine regains (number)km/ (TownName)”. Russians taking land is either seemingly not reported or phrased as “Russia says its forces have improved positions in / captured (Location)”. Only mentions of Russian gains are phrased to reference killing (forces is a useful homonym). Ukraine gains are phrased as the entire country reclaiming rightful stake (regains implies they were there first, and the region’s history is vastly more complex than that).

Israel headlines though refer to either the entire country “appropriating” space or for the really murderous stuff it specifies the IDF as the perpetrators. The whole country headline versions sound temporary and even morally neutral, while the obviously indefensible genocide can be compartmentalised as only being the military and harsh realities of war. They even get to disconnect the word Israel by only ever saying the initialism IDF.

They’re three different characterisations entirely of the same act by different countries - killing each other to control politically strategic physical space ownership.

I hope one day people can realise we’re all just being used as disposable pawns targeting other humans, who are also just trying to live peacefully in this dystopian civilisation. None of the headlines about suffering ever needed to happen. We all need to stop whatever it is we do that contributes to those who rule us and would have us die for them.

Oof. I have a different musculoskeletal problem with a far less interesting story behind it, but functionally a quite similar limitation that also prevents much… verticality. I completely hear you on the mindless zombie complications too, it’s fucking awful. I’m sorry we have both found ourselves in this shitty boat!

The meal makes good sense. 30 mins is a fair bit though, so I can see why you space it our that far.

If you ever feel like something a little different, maybe one of my tricks might help you. I order delivery… but I extend it out by nuking potatoes and frozen vegetables. A potato the size of my fist takes 3 mins 30 in my microwave, broccoli and spinach similar from frozen. The tinned tomatoes I buy are also a “heat up and add flavors” quick option because they’re not watery.

One curry from my local Indian place that has way too much sauce turns into 3 meals with a much better nutritional balance when I dump any or all of those in. They’re done before the food even arrives, i don’t have to watch an appliance with a flame, or clean much, and the cost per portion reduces to something sensible.

opioids made me intolerant to dairy,

TIL that’s a thing. I just have to ration mine to a ridiculous degree at a low dosage or i get the more common peristalsis problems in a very unpleasant way.

I’m managing the rollercoaster ride to make the ups and downs as tolerable as I can.

Amen. And I wish you the best of luck in doing so.

Can I ask how this particular meal works with your limitations? I have strategies I’ve had to implement too, so I’m always interested in how others manage.

In Australia, it’s not too uncommon to hear people have conversations about how fucked the US system is. That’s partly a symptom of how intertwined my life is with the topic of medicine and healthcare systems though, I’m sure most people have far fewer discussions about those topics than I do.

Having said that, I have certainly said “Thank God I’m not in the US” and received emphatic agreement in conversations.

I’ve also had a doctor say “well at least you’re not in the US” to me during an appointment, after I expressed some displeasure at how much something was going to cost me - because i wasn’t considered a valid demographic for that specific drug to receive the subsidy.

Socialised medicine doesn’t mean free medicine, sadly. And our system has been run down by the ruling class attempting to emulate the US version’s money-churning machine.

I never want to hear anyone try to say NATO isn’t just an international military that is guided / deeply influenced by American foreign policy ever again. One of the few good things to ever come from the Trump fiasco is that they’re finally saying the quiet parts out loud, but the fact that this will receive no coverage, let alone criticism, means that might just be even more dangerous for all of us, even outside the Atlantic.

The world is on fire and humanity is prioritising manufacturing our own suicide above investing in fire extinguishers.